Mease P J
Seattle Rheumatology Associates, WA 98104, USA.
Ann Rheum Dis. 2002 Apr;61(4):298-304. doi: 10.1136/ard.61.4.298.
High levels of proinflammatory cytokines, including tumour necrosis factor (TNF), have been detected in psoriatic skin lesions and joints of patients with the inflammatory disease. Early results of treatment of psoriatic arthritis and psoriasis with TNF neutralising agents are encouraging, but whether these agents will be able to improve long term outcomes, such as disability, is not yet known.
在炎症性疾病患者的银屑病皮肤病变和关节中已检测到高水平的促炎细胞因子,包括肿瘤坏死因子(TNF)。使用TNF中和剂治疗银屑病关节炎和银屑病的早期结果令人鼓舞,但这些药物是否能够改善长期预后,如残疾情况,尚不清楚。