ILT3和ILT4的高表达是耐受性树突状细胞的一个普遍特征。
High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells.
作者信息
Manavalan John S, Rossi Paola C, Vlad George, Piazza Flavia, Yarilina Anna, Cortesini Raffaello, Mancini Donna, Suciu-Foca Nicole
机构信息
Department of Pathology and Internal Medicine, Columbia University, 630 West 168th Street, P&S 14-401, New York, NY 10032, USA.
出版信息
Transpl Immunol. 2003 Jul-Sep;11(3-4):245-58. doi: 10.1016/S0966-3274(03)00058-3.
The direct interaction between antigen specific CD8(+) CD28(-) T suppressor cells (T(S)) with dendritic cells (DC) results in the tolerization of DC by inducing the upregulation of immunologlobulin like transcript 3 (ILT3) and ILT4. We show here that such tolerogenic DC anergize alloreactive CD4(+) CD45RO(+) CD25(+) T cells converting them into regulatory T cells (T(R)), which in turn, continue the cascade of suppression by tolerizing other DC. Interleukin 10 (IL-10) and interferon-alpha (IFN-alpha) also induce ILT3 and ILT4 upregulation in DC, rendering them tolerogenic. This implies a common mechanism of DC-mediated suppression. This finding and the observation that in organ allograft recipients quiescence is associated with the presence in the circulation of donor-specific T(S) and T(R) emphasize the importance of the cross talk between tolerogenic DC and T cells in suppression of the immune response.
抗原特异性CD8(+) CD28(-) T抑制细胞（T(S)）与树突状细胞（DC）之间的直接相互作用，通过诱导免疫球蛋白样转录物3（ILT3）和ILT4的上调，导致DC的耐受。我们在此表明，这种致耐受性DC使同种异体反应性CD4(+) CD45RO(+) CD25(+) T细胞失能，将它们转化为调节性T细胞（T(R)），而T(R)继而通过使其他DC耐受来延续抑制级联反应。白细胞介素10（IL-10）和干扰素-α（IFN-α）也诱导DC中ILT3和ILT4上调，使其具有耐受性。这意味着DC介导的抑制存在共同机制。这一发现以及在器官同种异体移植受者中观察到的静止状态与循环中供体特异性T(S)和T(R)的存在相关，强调了致耐受性DC与T细胞之间的相互作用在抑制免疫反应中的重要性。
Zotero 插件