Xiao Y H, Chen D P, Yan J H, Yokoyama Y
Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Second Medical University, China.
Eur J Gynaecol Oncol. 2002;23(1):63-7.
This study was designed to examine the therapeutic effectiveness and mechanism of action of Tripterygium Wilfordii polyglycoside (TWP) in the treatment of endometriosis.
An experimental endometriosis model was developed using New Zealand White rabbits where endometrial tissue was autotransplanted into the peritoneum. Six weeks after transplantation, a total of 22 rabbits were randomly placed into two groups: Group I (n=17) was treated with TWP (10 mg/kg/day) and Group 2 (n=5) served as the water-fed control for three successive months. The volume of endometrial implants was measured before and after administration of TWP and water. Immune and endocrine systems were investigated in the normal phase, six weeks after induction of endometriosis, and three months after TWP treatment and water administration.
After treatment with TWP, the average volume of endometrial implants significantly decreased (p < 0.0001), and the antiendometrial antibody (EmAb) level decreased (p < 0.05) to near normal levels, but it did not decrease in the untreated controls. Serum FSH and LH levels also decreased after TWP treatment. Furthermore, electron microscopic examination of the pituitary ultrastructure revealed morphological changes in gonadotropic cells (G-cell) after treatment with TWP, and changes gradually disappeared four weeks after withdrawal of TWP.
This study indicates that TWP has both hormonal and immune system action that is effective as a medical treatment for experimental endometriosis by modulating both reproductive endocrine functions and immunosuppression that results in remission of the disease.
本研究旨在探讨雷公藤多苷（TWP）治疗子宫内膜异位症的疗效及作用机制。
采用新西兰白兔建立实验性子宫内膜异位症模型，将子宫内膜组织自体移植到腹膜。移植6周后，将22只兔子随机分为两组：第1组（n = 17）用TWP（10 mg/kg/天）治疗，第2组（n = 5）作为饮水对照组，连续3个月。在给予TWP和水前后测量子宫内膜移植灶的体积。在正常期、诱导子宫内膜异位症6周后、TWP治疗和饮水3个月后研究免疫和内分泌系统。
TWP治疗后，子宫内膜移植灶的平均体积显著减小（p < 0.0001），抗子宫内膜抗体（EmAb）水平降低（p < 0.05）至接近正常水平，但未治疗的对照组未见降低。TWP治疗后血清FSH和LH水平也降低。此外，垂体超微结构的电子显微镜检查显示，TWP治疗后促性腺细胞（G细胞）出现形态学变化，停药4周后变化逐渐消失。
本研究表明，TWP具有激素和免疫系统作用，通过调节生殖内分泌功能和免疫抑制，对实验性子宫内膜异位症有治疗作用，可使疾病缓解。
