Yu Yang, Zhu Yufei, Gao Mengyao, Wang Yu, Li Shiying, Gou Ying
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Department of Obstetrics and Gynecology, Postdoctoral Mobile Station of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Front Pharmacol. 2025 Jul 9;16:1624569. doi: 10.3389/fphar.2025.1624569. eCollection 2025.
Endometriosis (EMs) is a prevalent benign gynecological disorder characterized by dysmenorrhea and infertility, significantly impacting women's health and quality of life. Currently, the pathogenesis of EMs remains incompletely elucidated. There are various side effects of drug treatment, while surgical interventions involve a certain degree of tissue trauma. Therefore, novel therapeutic drugs and clinical strategies should be developed. Apoptosis, a programmed cell death pathway, maintains tissue homeostasis, and its dysregulation is linked to various diseases and pathological complexities. Accumulating evidence suggests that abnormal apoptosis is intricately linked to the development and progression of EMs and that targeted promotion of cell apoptosis may contribute to the prevention and treatment of EMs. Natural metabolites, with their biological properties such as multipathway and multitarget effects, exhibit unique advantages in treating EMs, possibly by regulating apoptosis. This paper reviews the relationship between apoptosis and EMs. It systematically summarizes the latest progress of natural metabolites in treating EMS by regulating apoptosis, offering an innovative strategy for treating EMs.
子宫内膜异位症（EMs）是一种常见的良性妇科疾病，其特征为痛经和不孕，对女性健康和生活质量有重大影响。目前，EMs的发病机制仍未完全阐明。药物治疗存在各种副作用，而手术干预则涉及一定程度的组织创伤。因此，应开发新的治疗药物和临床策略。细胞凋亡是一种程序性细胞死亡途径，维持组织稳态，其失调与各种疾病和病理复杂性相关。越来越多的证据表明，异常细胞凋亡与EMs的发生和发展密切相关，靶向促进细胞凋亡可能有助于EMs的预防和治疗。天然代谢产物具有多途径、多靶点作用等生物学特性，在治疗EMs方面具有独特优势，可能通过调节细胞凋亡发挥作用。本文综述了细胞凋亡与EMs的关系。系统总结了天然代谢产物通过调节细胞凋亡治疗EMs的最新进展，为治疗EMs提供了创新策略。
