Becelli R, Perugini M, Mastellone P, Frati R
Dept. of Maxillo Facial Surgery, University of Rome La Sapienza, Rome, Italy.
J Exp Clin Cancer Res. 2001 Dec;20(4):487-9.
From 1989 to 1999 a retrospective study was conducted on 7 patients with recurrent pleomorphic adenomas of the parotid gland who were referred to the MaxilloFacial Department of the University of Rome "La Sapienza" after having undergone surgery elsewhere. The mean time interval between the first operation and recurrences ranged from 15 months to 13 years, and the average time interval was 7.7 years. Implantability of the lesion and inadequate surgery that produced rupture of tumour capsule and tumour cells bleeding into surrounding glandular parenchyma, were the reasons for tumour recurrence. The instrumental examinations used for planning the surgical treatment to be applied and for studying the relations of recurrence with glandular parenchyma were CT (with contrast medium) or MR of head and neck. These patients underwent total parotidectomy with facial nerve preservation and no recurrence occurred in any patient. The results of this study underscore the importance of adequate surgical excision of initial recurrences as well as primary tumours to prevent tumour recidivism. Finally, tumour control rates and facial nerve preservation are enhanced with formal parotidectomy for recurrent tumour when feasible.
1989年至1999年，对7例腮腺复发性多形性腺瘤患者进行了一项回顾性研究，这些患者在其他地方接受手术后被转诊至罗马“La Sapienza”大学颌面科。首次手术与复发之间的平均时间间隔为15个月至13年，平均时间间隔为7.7年。病变的可植入性以及手术不充分导致肿瘤包膜破裂和肿瘤细胞渗入周围腺实质，是肿瘤复发的原因。用于规划手术治疗方案以及研究复发与腺实质关系的影像学检查为头部和颈部的CT（增强扫描）或磁共振成像（MR）。这些患者均接受了保留面神经的全腮腺切除术，无一例复发。本研究结果强调了对初次复发肿瘤以及原发肿瘤进行充分手术切除以防止肿瘤复发的重要性。最后，对于复发性肿瘤，在可行的情况下，行正规腮腺切除术可提高肿瘤控制率并保留面神经。
