Williamson H E, Bourland W A, Marchand G R, Farley D B, Van Orden D E
Proc Soc Exp Biol Med. 1975 Oct;150(1):104-6. doi: 10.3181/00379727-150-38982.
Levels of PGE in renal venous blood were found to be significantly elevated at the time RBF was increased by furosemide. Following indomethacin, a second dose of furosemide failed to increase RBF and levels of PGE in renal venous blood were not elevated. Levels of PGF and PGA were not affected by furosemide. The increase of PGE in renal venous blood at the time of renal dilation supports the hypothesis that furosemide increases RBF by releasing PGE. An intrarenal action of the released PGE is implied by this mechanism.
在使用速尿使肾血流量增加时，发现肾静脉血中前列腺素E（PGE）水平显著升高。给予消炎痛后，再次给予速尿未能增加肾血流量，且肾静脉血中PGE水平未升高。前列腺素F（PGF）和前列腺素A（PGA）水平不受速尿影响。肾扩张时肾静脉血中PGE增加支持了速尿通过释放PGE增加肾血流量这一假说。该机制提示所释放的PGE存在肾内作用。
