Nolan C M, Clark R A, Beaty H N
Proc Soc Exp Biol Med. 1975 Oct;150(1):134-6. doi: 10.3181/00379727-150-38989.
Chemotactic activity was assayed in CSF of rabbits with pneumococcal meningitis to further characterize the inflammatory response in this infection. CSF chemotactic activity was detected in increasing levels for 72 hr after infection. Activity was stable at 56 degrees and was inactivated by agents which denature proteins. Gel filtration demonstrated two chemotactically active fractions in infected CSF with mol wts of approximately 3000 and 11,000. Bacterial products appear to account for a portion of the observed CSF chemotactic activity, but the role of host factors remains to be clarified.
对患有肺炎球菌性脑膜炎的兔子的脑脊液进行趋化活性测定，以进一步描述这种感染中的炎症反应特征。感染后72小时内，脑脊液趋化活性水平不断升高。该活性在56摄氏度时稳定，且可被使蛋白质变性的试剂灭活。凝胶过滤显示，感染的脑脊液中有两个趋化活性组分，分子量分别约为3000和11000。细菌产物似乎占观察到的脑脊液趋化活性的一部分，但宿主因素的作用仍有待阐明。
