[The protective effects on postburn renal function by early enteral feeding in burned rats].

OBJECTIVE

To study the effects of enteral feeding on postburn renal function in rats and its possible mechanism.

METHODS

Wistar rats inflicted with 30% TBSA skin burn were adopted as the model. The effects of early enteral feeding (EEF) were dynamically observed on the changes of intra-gastric mucosal pH (pHi), portal endotoxin level, renal water content, plasma level of tumor necrosis factoralpha (TNFalpha), serum BUN and Cr contents and endogenous creatinine clearance rate.

RESULTS

Compared with that in simple burn group, the pHi decrease could be inhibited by EEF, the portal endotoxin level, plasma TNFalpha level and renal water content were decreased by the action of EEF. Serum BUN, Cr contents were not affected by EEF. But the CCr increased by 4.67 times [from (16.43 +/- 2.9) to (3.52 +/- 0.79), P < 0.01] with EEF.

CONCLUSION

EEF could obviously improve postburn renal function in severely burned rats, which might be related to the decrease of enteral endotoxin translocation and the postburn release of inflammatory mediators.