Guo Z, Li L, Zhao L
Burn Institute, 304th Hospital of PLA, Beijing 100037, P.R.China.
Zhonghua Shao Shang Za Zhi. 2000 Oct;16(5):286-8.
To observe postburn metabolic characteristics of zinc and its influence on copper, iron, calcium.
(1) To analyze the levels of Zn, Cu, Fe, Ca in the serum and urine of burn patient on different postburn days. (2) To replicate a rat model of zinc deficiency and to observe the symptoms and the effects of zinc supplementation in different dosage after scalding in rats with zinc deficiency. (3) To assay the levels of Zn, Cu, Fe, Ca in rat wound tissues following supplementation of zinc in diet and to wounds in rats after scald.
(1) The levels of serum Zn and Cu decreased markedly on 1 similar 3 days in major burn patients, whereas the urine Zn and Cu increased obviously, reaching the peak value on the 14th day. The serum and urine Fe increased rapidly on PBD2 and then descended steeply. The serum and urine Ca kept lower levels all along. (2) In zinc deficient rats growth retardation appeared first and other symptoms emerged subsequently. Serum Zn decreased and serum Cu, Fe, Ca increased. (3) The levels of Zn, Cu, Fe, Ca in wound tissue of scalded rats showed a continuous postburn increase. The Ca contents in wound tissue increased about 50 -- fold. Zn content in wound was more obviously increased than Cu, Fe and Ca when Zn was supplemented through wound compared with that with diet supplementation.
Serum Zn level was lowered after scald and it could be elevated after supplementing zinc by diet or through wound, Changes in serum Cu, Fe, Ca occurred corresponding to the change in serum Zn.
观察烧伤后锌的代谢特点及其对铜、铁、钙的影响。
（1）分析烧伤患者不同伤后时间血清和尿液中锌、铜、铁、钙的含量。（2）复制缺锌大鼠模型，观察缺锌大鼠烫伤后不同剂量补锌的症状及效果。（3）测定饮食补锌及烫伤大鼠创面补锌后大鼠创面组织中锌、铜、铁、钙的含量。
（1）大面积烧伤患者伤后1～3天血清锌和铜明显降低，而尿锌和尿铜明显升高，14天达峰值。伤后第2天血清和尿铁迅速升高，随后急剧下降。血清和尿钙一直维持在较低水平。（2）缺锌大鼠首先出现生长迟缓，随后出现其他症状。血清锌降低，血清铜、铁、钙升高。（3）烫伤大鼠创面组织中锌、铜、铁、钙含量伤后持续升高。创面组织中钙含量增加约50倍。与饮食补锌相比，创面补锌时创面锌含量升高比铜、铁、钙更明显。
烫伤后血清锌水平降低，经饮食或创面补锌后可升高，血清铜、铁、钙的变化与血清锌的变化相应。
