Dastych M, Jezek P, Richtrová M
Z Gastroenterol. 1986 Mar;24(3):157-60.
The application of Penicillamine (750 mg per day) for one year resulted in the expected increase of urinary copper excretion (8-10 fold). The increase of Zinc excretion was only moderate (2 fold). The application of Penicillamine did not influence the excretion of Ca, Mg and Fe. We did not find a decrease of Zinc content in the hair of patients after one year treatment. The serum concentration of Zn, Cu, Fe, Ca and Mg was not influence by the application of Penicillamine. Thus, a treatment with Penicillamine is not a probable cause of zinc deficiency in liver disease.
每日应用青霉胺（750毫克）一年导致尿铜排泄量出现预期增加（增加8至10倍）。锌排泄量仅适度增加（增加2倍）。青霉胺的应用未影响钙、镁和铁的排泄。在一年的治疗后，我们未发现患者头发中的锌含量降低。青霉胺的应用未影响锌、铜、铁、钙和镁的血清浓度。因此，用青霉胺治疗不是肝病中锌缺乏的可能原因。
