Qian Kun, Wan Zhi, Hao Lang-Song, Zhang Ming-Ming, Zhou Yong, Wu Xiao-Ting
Department of General Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu 610041, Sichuan Province, China.
World J Gastroenterol. 2007 Dec 14;13(46):6259-63. doi: 10.3748/wjg.v13.i46.6259.
To investigate the effects of short-term application of low-dose growth hormone on trace element metabolism and blood glucose in surgical patients.
A total of 48 consecutive patients undergoing abdominal operations were randomized to receive either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) injections daily for 7 d after surgery. The two groups had similar nutrition intake. Blood, feces, urine and drain samples were collected to measure zincum, cuprum and ferrum as well as glucose levels. Accumulative intake, excretion and balance of zincum, cuprum and ferrum, apparent absorption (AA) and apparent utilization (AU) of zincum, cuprum and ferrum, blood glucose levels and adverse events were estimated.
There were no differences in accumulative intake and drain excretion between the two groups. The feces excretion and accumulative excretion of cuprum were lower in the rhGH group (P < 0.05). The urinary excretion of zincum, cuprum and ferrum was all significantly decreased in the rhGH group (P < 0.05) and the accumulative balance of zincum, cuprum and ferrum was improved compared with the placebo group (P < 0.05). AA of cuprum in the rhGH group was almost twice as much as the placebo group (P < 0.05), and AU of zincum, cuprum and ferrum was all improved in the rhGH group (P < 0.05). The mean blood glucose level was significantly higher in the rhGH group than in the placebo group from d 3 to d 6 after operation (P < 0.05).
Postoperative low-dose rhGH treatment improves the retention of zincum, cuprum and ferrum and decreases the excretion of zincum, cuprum and ferrum, improves the balance of zincum, cuprum and ferrum, and promotes the AA and AU of zincum, cuprum and ferrum. rhGH can be well tolerated without significant adverse effects and the blood glucose level can be well controlled.
探讨短期应用小剂量生长激素对手术患者微量元素代谢及血糖的影响。
选取48例连续接受腹部手术的患者，随机分为两组，术后7天内分别每日皮下注射重组人生长激素（rhGH，0.15 IU/kg）或安慰剂（月经血）。两组患者营养摄入量相似。收集血液、粪便、尿液及引流液样本，检测锌、铜、铁以及血糖水平。估算锌、铜、铁的累积摄入量、排泄量及平衡量，锌、铜、铁的表观吸收率（AA）和表观利用率（AU），血糖水平及不良事件。
两组患者的累积摄入量及引流液排泄量无差异。rhGH组铜的粪便排泄量及累积排泄量较低（P<0.05）。rhGH组锌、铜、铁的尿液排泄量均显著降低（P<0.05），与安慰剂组相比，锌、铜、铁的累积平衡得到改善（P<0.05）。rhGH组铜的AA几乎是安慰剂组的两倍（P<0.05），rhGH组锌、铜、铁的AU均得到改善（P<0.05）。术后第3天至第6天，rhGH组的平均血糖水平显著高于安慰剂组（P<0.05）。
术后小剂量rhGH治疗可改善锌、铜、铁的潴留，减少锌、铜、铁的排泄，改善锌、铜、铁的平衡，促进锌、铜、铁的AA和AU。rhGH耐受性良好，无明显不良反应，血糖水平可得到良好控制。
