Barone J P, Nancollas G H, Tomson M
Calcif Tissue Res. 1976 Dec 2;21(3):171-82. doi: 10.1007/BF02547394.
The kinetics of growth of calcium phosphate on synthetic HAP seed crystals has been studied at 37 degrees C and at pH values of 4.5 and 5.0 by the pH-stat controlled addition of base. Following an induction, DCPD crystal growth takes place with growth kinetics characteristic of the crystallization of pure DCPD seed. The effect of stirring rate, HAP seed concentration and initial degree of supersaturation with respect to DCPD on the kinetics of the growth process have been determined. The crystallization appears to be controlled by a surface reaction and nucleation of DCPD on the HAP substrate is completed in the initial induction period. Formation of DCPD under these conditions closely simulates plaque and calculus production in the mouth. Thus calculus that develops from the initial plaque is known to contain an appreciable amount of DCPD.
通过pH计控制碱的添加，在37℃以及pH值为4.5和5.0的条件下，研究了磷酸钙在合成羟基磷灰石（HAP）籽晶上的生长动力学。经过诱导期后，二水磷酸氢钙（DCPD）晶体开始生长，其生长动力学具有纯DCPD籽晶结晶的特征。已确定搅拌速率、HAP籽晶浓度以及相对于DCPD的初始过饱和度对生长过程动力学的影响。结晶似乎受表面反应控制，并且在初始诱导期内，DCPD在HAP底物上的成核过程完成。在这些条件下DCPD的形成与口腔中牙菌斑和牙结石的产生密切相似。因此，已知由初始牙菌斑形成的牙结石含有相当数量的DCPD。
