White A G, Nachev P
Proc Soc Exp Biol Med. 1975 Oct;150(1):261-3. doi: 10.3181/00379727-150-39016.
Dialysates of rat uremic serum were incubated with Pronase, Carboxypeptidase A, Leucine Aminopeptidase, or Trypsin to investigate whether these enzymes might destroy the inhibitory effects of the dialysates on the uptake of paraaminohippurate by rat renal cortical slices or the uptake of purines by rat liver slices. Of these enzymes, Pronase produced the greatest destruction (63.2 +/- 4.5%) of the inhibitory action on renal transport, with a much smaller destruction (17.8 +/- 2.1%) of the inhibitory effect on hepatic transport.
将大鼠尿毒症血清的透析液与链霉蛋白酶、羧肽酶A、亮氨酸氨肽酶或胰蛋白酶一起孵育，以研究这些酶是否会破坏透析液对大鼠肾皮质切片摄取对氨基马尿酸或大鼠肝切片摄取嘌呤的抑制作用。在这些酶中，链霉蛋白酶对肾脏转运抑制作用的破坏最大（63.2±4.5%），而对肝脏转运抑制作用的破坏要小得多（17.8±2.1%）。
