Drane Daniel L, Yuspeh Robert L, Huthwaite Justin S, Klingler Lacey K
Department of Neurology, Regional Epilepsy Center, University of Washington School of Medicine, Seattle, Washington 98104-2499, USA.
Neuropsychiatry Neuropsychol Behav Neurol. 2002 Mar;15(1):39-43.
The Trail Making Test (TMT) is a psychomotor task that is used routinely in clinical evaluations and consists of two parts: TMT-A and TMT-B. The purpose of the present study was to examine the relations of two derived-TMT indices with age, education, and gender and to establish normative data.
Prior research has suggested that these derived indices provide purer measures of the executive skills required to complete TMT-B. It has also been suggested that these scores can be effectively used to detect cognitive impairment, and that they are relatively free from the impact of age.
Difference scores (B minus sign A) and ratio scores (B:A) were computed from the TMT performance of 285 adults who have no history of substance abuse or psychiatric or neurologic disorder and who are not currently being treated with any type of psychotropic medication.
Subjects ranged in age from 18 to 90 years and in education level from 6 to 20 years. For the entire sample, (B minus sign A) scores ranged from 6 to 248 seconds (M, 62.15; SD, 49.44), and (B:A) scores ranged from 1.23 to 9.54 (M, 2.81; SD, 1.13). Significant correlations were noted with age and (B minus sign A) and (B:A) scores, accounting for 28% and 6% of the variance, respectively. Subjects were assigned to one of eight age groups, which were formed by decade. Univariate analyses of variance were significant for (B minus sign A) (p < 0.0001) and (B:A) (p < 0.0004) scores. Post hoc analyses indicated that the two oldest age groups had significantly larger (B minus sign A) scores than the younger age groups. However, post hoc analyses with (B:A) scores indicated that only the 70-79-year-old age group significantly differed from the three youngest age groups. No other age groups significantly differed from another on this measure.
Normative data are presented for clinical use, and recommendations are made for future research. In addition, the current results suggest that normal aging has a significant impact on cognitive flexibility and indicate that previous suggestions for impairment cut-off scores based on the (B:A) ratio may result in erroneous classification of healthy older adults.
连线测验(TMT)是一项心理运动任务,常用于临床评估,包括两个部分:TMT - A和TMT - B。本研究的目的是检验两个衍生的TMT指标与年龄、教育程度和性别的关系,并建立常模数据。
先前的研究表明,这些衍生指标能更纯粹地衡量完成TMT - B所需的执行技能。也有人提出,这些分数可有效用于检测认知障碍,且相对不受年龄影响。
从285名无药物滥用史、精神或神经疾病史且目前未接受任何类型精神药物治疗的成年人的TMT表现中计算出差值分数(B减去A)和比率分数(B:A)。
受试者年龄在18至90岁之间,教育水平在6至20年之间。对于整个样本,(B减去A)分数范围为6至248秒(均值,62.15;标准差,49.44),(B:A)分数范围为1.23至9.54(均值,2.81;标准差,1.13)。年龄与(B减去A)和(B:A)分数之间存在显著相关性,分别解释了28%和6%的方差。受试者被分为八个年龄组之一,按十年划分。(B减去A)(p < 0.0001)和(B:A)(p < 0.0004)分数的单因素方差分析具有显著性。事后分析表明,两个年龄最大的年龄组的(B减去A)分数显著高于较年轻的年龄组。然而,(B:A)分数的事后分析表明,只有70 - 79岁年龄组与三个最年轻年龄组有显著差异。在该指标上,其他年龄组之间无显著差异。
给出了供临床使用的常模数据,并对未来研究提出了建议。此外,当前结果表明正常衰老对认知灵活性有显著影响,并表明先前基于(B:A)比率的损伤截断分数建议可能导致对健康老年人的错误分类。