Abramov A V, Kolesnik Iu M
Department of Pathophysiology, Medical University of Zaporozhye.
Morfologiia. 2001;120(5):46-51.
5 weeks development of streptozoticin-induced diabetes mellitus in the rats is accompanied with the increase of gastrin-releasing peptide (GRP) immunopositive neurons amount in parvocellular neurosecretory subdivisions of immunopositive fibers increased in these structures:the content of GRP increased in median eminence as well. In supraoptic nucleus and posterior magnocellular subdivision of paraventricular nucleus the amount of GRP-immunopositive neurons increased by the second week of diabetes development with its decrease by the fifth week. Thus, the increase of GRP synthesis in hypothalamic neurosecretory structures in diabetes mellitus may be considered as a compensatory reaction directed on the activation of the central mechanisms of feeding restriction and stimulation of insulin synthesis in the pancreas.
链脲佐菌素诱导的大鼠糖尿病5周发展过程中，胃泌素释放肽（GRP）免疫阳性神经元数量在免疫阳性纤维的小细胞神经分泌亚群中增加，这些结构中免疫阳性纤维也增加：正中隆起中GRP的含量也增加。在视上核和室旁核的后部大细胞亚群中，糖尿病发展第二周时GRP免疫阳性神经元数量增加，而到第五周时减少。因此，糖尿病时下丘脑神经分泌结构中GRP合成的增加可被视为一种代偿反应，旨在激活限制进食的中枢机制并刺激胰腺中胰岛素的合成。
