Greene M H, Glaubiger D L, Mead G D, Fraumeni J F
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2043-6.
Among 31 long-term survivors of Ewing's sarcoma, two patients developed second primary cancers, compared to an expected number of 0.03 (relative risk = 72; 95% confidence limit = 8-259). One patient had renal medullary neuroblastoma, which is not known to be related to Ewing's tumor or its therapy. The second patient had a bone fibrosarcoma, arising at the primary tumor site, which was thought to be radiation-induced. The risk of radiation-induced bone sarcomas was lower, although not significantly so, than in a recently reported series of Ewing's tumor. These two reports suggest that patients with Ewing's sarcoma have a tendency to develop radiogenic sarcomas following primary megavoltage radiation therapy. The lowest radiation dose consistent with local tumor eradication should be employed to minimize the risk of subsequent radiogenic cancer.
在31例尤因肉瘤长期存活者中，有2例发生了第二原发性癌症，而预期数量为0.03（相对风险=72；95%置信区间=8-259）。1例患者患有肾髓质神经母细胞瘤，目前尚不清楚其与尤因肿瘤或其治疗方法的关系。第二例患者患有骨纤维肉瘤，发生在原发肿瘤部位，被认为是辐射诱发的。与最近报道的一系列尤因肿瘤相比，辐射诱发骨肉瘤的风险较低，尽管差异不显著。这两份报告表明，尤因肉瘤患者在接受原发性兆伏放疗后有发生放射性肉瘤的倾向。应采用与局部肿瘤根除相一致的最低辐射剂量，以尽量降低随后发生放射性癌症的风险。
