Buhi William C
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL 32610-0294, USA.
Reproduction. 2002 Mar;123(3):355-62. doi: 10.1530/rep.0.1230355.
During late follicular growth, oestrus, fertilization and early embryonic development, the oviduct, under specific hormonal control, produces fluid and contributes secretory macromolecules that optimize the microenvironment for gamete maturation and transport, fertilization and early cleavage-stage embryonic development. This review describes the state of knowledge concerning the physiological and biochemical characterization of the major oviduct secreted protein, the oviduct-specific, oestrogen-dependent glycoprotein. The identification, localization within the oviduct, binding and association with oocytes, embryos and spermatozoa, hormonal control of gene expression, cloning, gene organization, protein sequences and post-translational modifications of oviduct-specific, oestrogen-dependent glycoprotein are discussed. Identification of biological functions for this glycoprotein, its interactions with spermatozoa, oocytes and embryos and its potential as a paracrine regulator of fertilization and development are also discussed.
在卵泡晚期生长、发情期、受精及早期胚胎发育过程中，输卵管在特定激素的控制下分泌液体并产生分泌性大分子，这些物质为配子成熟与运输、受精及早期卵裂期胚胎发育优化微环境。本综述描述了关于输卵管主要分泌蛋白——输卵管特异性雌激素依赖糖蛋白的生理生化特征的知识现状。文中讨论了该蛋白的鉴定、在输卵管内的定位、与卵母细胞、胚胎及精子的结合与关联、基因表达的激素调控、克隆、基因结构、蛋白质序列及翻译后修饰。还讨论了该糖蛋白生物学功能的鉴定、其与精子、卵母细胞及胚胎的相互作用以及作为受精与发育旁分泌调节因子的潜力。
