Ray B, Mallick H, Kumar V M
Department of Physiology, All India Institute of Medical Sciences, New Delhi-110 029.
Indian J Physiol Pharmacol. 2001 Oct;45(4):445-50.
This study was conducted to find out whether the medial preoptic area (mPOA) plays a role in the selection of ambient temperature by rats. Adult male Wistar rats were kept in an environmental chamber having three interconnected compartments, maintained at three different temperatures (18 degrees, 24 degrees and 30 degrees C) in which the animals could move freely from one compartment to the other. Normal rats preferred to stay at the chamber maintained at 24 degrees C for most of the time, during day and night. The temperature preference shifted to 30 degrees C after the mPOA of these rats had been lesioned by local administration of 5 micrograms of N-methyl D-aspartic acid (NMDA) in 0.2 microliter distilled water. The results of the study suggest that the mPOA acts as a fine tuning center for homeostatic regulation of thermal balance, including selection of appropriate thermal environment. It is proposed that after the mPOA lesion, the animal cannot assess properly the energy status of the body and thereby prefers a higher ambient temperature.
本研究旨在探究内侧视前区（mPOA）是否在大鼠选择环境温度中发挥作用。成年雄性Wistar大鼠被饲养在一个具有三个相互连通隔室的环境舱中，这三个隔室分别维持在三种不同温度（18摄氏度、24摄氏度和30摄氏度），动物可以在各隔室之间自由移动。正常大鼠在白天和夜晚的大部分时间里更喜欢待在维持在24摄氏度的隔室中。在这些大鼠的mPOA通过在0.2微升蒸馏水中局部注射5微克N-甲基-D-天冬氨酸（NMDA）而受损后，温度偏好转移到了30摄氏度。该研究结果表明，mPOA作为热平衡稳态调节的微调中心，包括选择合适的热环境。有人提出，在mPOA受损后，动物无法正确评估身体的能量状态，从而更喜欢较高的环境温度。
