Holmström H, Rank F, Zederfeldt B
Scand J Plast Reconstr Surg. 1975;9(2):81-6. doi: 10.3109/02844317509022770.
Histological studies were performed on granulation tissue from cylinders implanted 2 to 8 weeks and 4 months in bipedicle tube flaps on rabbits. Tissue from cylinders implanted in skin folds were used as controls. Flap and control tissue showed similar changes over the weeks. At weeks 2 and 3 the tissue was rich in cells, blood vessels and collagenous fibres. At week 4 the tissue showed transitional changes to week 5, when there were zones of loosely textured tissue with fine, fragmented collagen fibres. At week 5 some of the loose tissue was replaced by fat. Macrophages and inflammatory cells had appeared. By week 7 the fatty and collagenous tissue was mature and macrophages and inflammatory cells had disappeared.
对植入兔双蒂管状皮瓣2至8周以及4个月的圆柱体的肉芽组织进行了组织学研究。植入皮肤褶皱处圆柱体的组织用作对照。数周内皮瓣和对照组织呈现出相似的变化。在第2周和第3周时，组织富含细胞、血管和胶原纤维。在第4周时，组织呈现出向第5周的过渡性变化，此时出现了质地疏松、胶原纤维细小且破碎的区域。在第5周时，一些疏松组织被脂肪取代。巨噬细胞和炎性细胞出现。到第7周时，脂肪和胶原组织成熟，巨噬细胞和炎性细胞消失。
