Holmström H, Ahonen J, Zederfeldt B
Scand J Plast Reconstr Surg. 1975;9(1):5-8. doi: 10.3109/02844317509022849.
The protein synthesis and the collagen synthesis by 2- to 7-week-old granulation tissue from implanted cylinders in bipedicle tube flaps on rabbits were measured in vitro by the incorporation of 14C-proline in proteins and in collagen hydroxyproline. Granulation tissue from cylinders implanted in skin folds were used as controls. In the skin flap group the protein synthesis was high at week 2, after which it decreased to week 5. In the controls the protein synthesis was the same as in the skin flap group at week 2. A decrease occurred between weeks 2 and 4 and a further decrease between weeks 6 and 7. At weeks 5 and 6 the protein synthesis was higher in the controls than in the skin flap group, but at week 7 it was the reverse. The collagen synthesis was high and equal in both groups at weeks 2 and 3 and then decreased to weeks 4 and 5. Between weeks 6 and 7 a further decrease was found in the controls, but not in the skin flap group.
通过将14C-脯氨酸掺入蛋白质和胶原羟脯氨酸中，在体外测量了兔双蒂管状皮瓣植入圆柱体后2至7周龄肉芽组织的蛋白质合成和胶原合成。将植入皮肤皱襞圆柱体的肉芽组织用作对照。在皮瓣组中，蛋白质合成在第2周时较高，之后在第5周时下降。在对照组中，蛋白质合成在第2周时与皮瓣组相同。在第2周和第4周之间出现下降，在第6周和第7周之间进一步下降。在第5周和第6周时，对照组的蛋白质合成高于皮瓣组，但在第7周时则相反。在第2周和第3周时，两组的胶原合成均较高且相等，然后在第4周和第5周时下降。在第6周和第7周之间，对照组进一步下降，但皮瓣组未出现下降。
