干扰素抑制乙型肝炎病毒复制需要蛋白酶体活性。
Inhibition of hepatitis B virus replication by interferon requires proteasome activity.
作者信息
Robek Michael D, Wieland Stefan F, Chisari Francis V
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Virol. 2002 Apr;76(7):3570-4. doi: 10.1128/jvi.76.7.3570-3574.2002.
Abstract
Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-alpha/beta) and IFN-gamma. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication.
摘要
乙型肝炎病毒（HBV）的复制受到α/β干扰素（IFN-α/β）和γ干扰素的非细胞病变方式抑制。我们在此证明，细胞蛋白酶体活性抑制剂可阻断这种抗病毒作用。这些结果表明，IFN诱导的抗病毒反应的一个关键组成部分可能是蛋白酶体依赖性降解HBV复制所需的病毒或细胞蛋白。
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