Liu Fengjun, Tang Hong
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Dec;26(6):1358-62, 1371.
In addition to immune regulation, interferon could suppress hepatitis B virus (HBV) replication through direct antiviral effect. After binding with the receptors on cell membrane, interferon directly inhibits HBV at different steps in HBV replication cycle by activating cell signaling cascades such as JAK-STAT pathway, interferon regulatory factor (IRFs) signaling pathway, and so on, followed by inducing a series of cytokines which are involved in regulation of the function of HBV enhancer I / X promoter (Ehn I / Xp). Also, interferon could induce the host cells to produce anti-viral proteins. This review describes the direct antiviral mechanism of interferon on HBV.
除免疫调节外，干扰素还可通过直接抗病毒作用抑制乙型肝炎病毒（HBV）复制。与细胞膜上的受体结合后，干扰素通过激活细胞信号级联反应，如JAK-STAT途径、干扰素调节因子（IRFs）信号通路等，在HBV复制周期的不同阶段直接抑制HBV，随后诱导一系列参与调节HBV增强子I/X启动子（Ehn I/Xp）功能的细胞因子。此外，干扰素可诱导宿主细胞产生抗病毒蛋白。本文综述了干扰素对HBV的直接抗病毒机制。
