甾体麻醉剂：3α-羟基-5α-孕甾烷-11,20-二酮-（21-¹⁴C）和3α,21-二羟基-5α-孕甾烷-11,20-二酮-（21-¹⁴C）21-乙酸酯的合成。
Steroidal anaesthetics: synthesis of 3alpha-hydroxy-5alpha-pregnane-11,20-dione-(21-14C) and 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione-(21-14C) 21-acetate.
作者信息
Ayres B E, Newall C E, Phillipps G H
出版信息
Steroids. 1975 Aug;26(2):219-25. doi: 10.1016/s0039-128x(75)80022-5.
PMID:1189005
Abstract
3alpha-Hydroxy-5alpha-pregnane-11,20-dione-[21-14C] and 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione-[21-14C] 21-acetate were prepared from a common radio-labelled intermediate, 21-diazo-3alpha-hydroxy-5alpha-pregnane-11,20-dione-[21-14C] 3-nitrate, obtained by the reaction of 17beta-chlorocarbonyl-3alpha-hydroxy-5alpha-androstan-11-one 3-nitrate with diazomethane-[14C].
摘要
3α-羟基-5α-孕烷-11,20-二酮-[21-¹⁴C]和3α,21-二羟基-5α-孕烷-11,20-二酮-[21-¹⁴C] 21-乙酸酯由一种共同的放射性标记中间体21-重氮-3α-羟基-5α-孕烷-11,20-二酮-[21-¹⁴C] 3-硝酸盐制备而成，该中间体通过17β-氯羰基-3α-羟基-5α-雄甾烷-11-酮3-硝酸盐与重氮甲烷-[¹⁴C]反应获得。
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