大鼠组织中阿法沙龙的分布情况。
Alphaxalone distribution in rat tissues.
作者信息
Pastorino A M, Favaretto P, Vallaperta P
出版信息
Arzneimittelforschung. 1979;29(2):204-6.
PMID:582131
Abstract
A method for the extraction and gaschromatographic determination of 3alpha-hydroxy-5alpha-pregnane-11,20-dione (alphaxalone, main active component of Althesin) in microgram amount in plasma and tissues is described. The slow i.v. infusion of Althesin in the rat gives uniform alphaxalone distribution in tissues, slight localization in the fat and brain levels comparable to plasma concentration.
摘要
本文描述了一种从血浆和组织中提取微克量的3α-羟基-5α-孕烷-11,20-二酮（阿法沙龙，阿尔西那的主要活性成分）并进行气相色谱测定的方法。给大鼠缓慢静脉输注阿尔西那后，阿法沙龙在组织中分布均匀，在脂肪中的定位较少，且脑内水平与血浆浓度相当。
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