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嗜肺军团菌的Dot/lcm转运体：一种囊泡运输的细菌调控因子，它协调在真核宿主中建立复制性细胞器。

The Dot/lcm transporter of Legionella pneumophila: a bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts.

作者信息

Roy Craig R

机构信息

Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA.

出版信息

Int J Med Microbiol. 2002 Feb;291(6-7):463-7. doi: 10.1078/1438-4221-00154.

DOI:10.1078/1438-4221-00154
PMID:11890545
Abstract

Legionella pneumophila are gram negative bacteria that parasitize professional phagocytes. When ingested by their eukaryotic hosts, these bacteria have the unique ability to alter maturation of the endocytic vacuoles in which they reside initially and create an organelle that supports replication. This review will focus on several scientific breakthroughs made recently that shed light on the mechanisms by which L. pneumophila are able to establish a niche permissive for intracellular growth.

摘要

嗜肺军团菌是寄生于专职吞噬细胞的革兰氏阴性菌。当被其真核宿主摄取后，这些细菌具有独特的能力来改变它们最初所在的内吞泡的成熟过程，并形成一个支持复制的细胞器。本综述将聚焦于最近取得的几项科学突破，这些突破揭示了嗜肺军团菌能够建立有利于细胞内生长的生态位的机制。

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The Dot/lcm transporter of Legionella pneumophila: a bacterial conductor of vesicle trafficking that orchestrates the establishment of a replicative organelle in eukaryotic hosts.嗜肺军团菌的Dot/lcm转运体：一种囊泡运输的细菌调控因子，它协调在真核宿主中建立复制性细胞器。
Int J Med Microbiol. 2002 Feb;291(6-7):463-7. doi: 10.1078/1438-4221-00154.
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Pore-forming activity is not sufficient for Legionella pneumophila phagosome trafficking and intracellular growth.成孔活性对于嗜肺军团菌吞噬体运输和细胞内生长并不充分。
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Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.嗜肺军团菌的dot/icm突变体快速逃逸至哺乳动物细胞和原生动物细胞的胞质溶胶中。
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Front Cell Infect Microbiol. 2017 Nov 30;7:485. doi: 10.3389/fcimb.2017.00485. eCollection 2017.
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mBio. 2015 Jun 9;6(3):e00595. doi: 10.1128/mBio.00595-15.
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Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.
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Front Cell Infect Microbiol. 2013 May 27;3:18. doi: 10.3389/fcimb.2013.00018. eCollection 2013.
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Screening-level assays for potentially human-infectious environmental Legionella spp.潜在可感染人类的环境军团菌属的筛查级检测
J Microbiol. 2011 Apr;49(2):200-7. doi: 10.1007/s12275-011-0233-z. Epub 2011 May 3.
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Characterization of a spontaneous avirulent mutant of Legionella pneumophila Serogroup 6: evidence of DotA and flagellin involvement in the loss of virulence.鉴定嗜肺军团菌血清群 6 型自发无毒突变株：DotA 和鞭毛蛋白参与毒力丧失的证据。
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