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日常生活活动无缺陷但存在持续行动能力缺陷:一种死亡风险因素。

Persistent mobility deficit in the absence of deficits in activities of daily living: a risk factor for mortality.

作者信息

Khokhar S R, Stern Y, Bell K, Anderson K, Noe E, Mayeux R, Albert S M

机构信息

Gertrude H. Sergievsky Center, Department of Neurology, New York, New York 10032, USA.

出版信息

J Am Geriatr Soc. 2001 Nov;49(11):1539-43. doi: 10.1046/j.1532-5415.2001.4911251.x.

Abstract

OBJECTIVES

To investigate the extent to which self-reported mobility deficit in the absence of impairment in activities of daily living (ADL) is associated with elevated mortality risk.

DESIGN

Prospective cohort study, with annual assessments of mobility and ADL status and ongoing monitoring of vital status.

SETTING

Population-based cohort drawn from Medicare enrollees in New York City.

PARTICIPANTS

One thousand two hundred ninety-eight older adults reporting functional status at baseline (1992-1994) and 2 years later.

MEASUREMENTS

Subjects reported mobility (e.g., walking, climbing stairs, and rising from a chair) and ADL (e.g., bathing, toilet use, dressing, grooming, and feeding) limitations. Two-year functional status trajectories were noted. We used two additional follow-up periods, at 2 and 4 years, to examine the likelihood that older people with mobility deficit may face an increased risk of death without first passing through a state of enduring ADL disability.

RESULTS

At 2 years, 12.7% had incident mobility deficit without ADL disability, and 21.3% were persistently disabled in mobility without ADL disability. Relative to subjects free of disability at baseline and follow-up, risk of mortality in the incident mobility deficit group was elevated at 2 and 4 years but did not achieve statistical significance. By contrast, for subjects with persistent mobility impairment who did not report ADL impairment, the mortality risk was significantly elevated both at 2 years (relative risk (RR) = 2.5; 95% confidence interval (CI) = 1.1-5.7)) and 4 years (RR = 2.9; 95% CI = 1.7-4.9)) of follow-up. Mortality was significantly elevated in this group in analyses restricted to respondents with no or only one comorbid condition.

CONCLUSION

Continuing, self-reported mobility impairment in the absence of ADL deficit is a risk factor for mortality. Older people with self-reported mobility deficit face an increased risk of mortality without first passing through enduring states of ADL disability.

摘要

目的

探讨在日常生活活动(ADL)无受损情况下自我报告的行动能力缺陷与死亡风险升高之间的关联程度。

设计

前瞻性队列研究,每年对行动能力和ADL状态进行评估,并持续监测生命状态。

背景

基于纽约市医疗保险参保者的人群队列。

参与者

1298名老年人在基线(1992 - 1994年)和2年后报告了功能状态。

测量

受试者报告行动能力(如行走、爬楼梯和从椅子上起身)和ADL(如洗澡、使用厕所、穿衣、修饰和进食)受限情况。记录了两年的功能状态轨迹。我们在2年和4年时使用了另外两个随访期,以研究行动能力有缺陷的老年人在未首先经历持续ADL残疾状态的情况下可能面临更高死亡风险的可能性。

结果

在2年时,12.7%的人出现了无ADL残疾的行动能力缺陷,21.3%的人持续存在无ADL残疾的行动能力残疾。与在基线和随访时无残疾的受试者相比,新出现行动能力缺陷组在2年和4年时的死亡风险有所升高,但未达到统计学显著性。相比之下,对于未报告ADL受损的持续行动能力受损受试者,在随访2年时(相对风险(RR)= 2.5;95%置信区间(CI)= 1.1 - 5.7))和4年时(RR = 2.9;95% CI = 1.7 - 4.9))死亡风险均显著升高。在仅限于无合并症或仅有一种合并症的受访者的分析中,该组的死亡率显著升高。

结论

在无ADL缺陷的情况下持续自我报告的行动能力受损是死亡的一个危险因素。自我报告行动能力有缺陷的老年人在未首先经历持续ADL残疾状态的情况下面临更高的死亡风险。

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