Catania Maria A, Marciano Maria C, Parisi Alessandra, Sturiale Alessio, Buemi Michele, Grasso Giovanni, Squadrito Francesco, Caputi Achille P, Calapai Gioacchino
Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, School of Medicine, University of Messina, Via Consolare Valeria, Policlinico Universitario Torre Biologica No. 5 piano 98124 Messina, Italy.
Eur J Pharmacol. 2002 Feb 22;437(3):147-50. doi: 10.1016/s0014-2999(02)01292-x.
Erythropoietin has recently been studied for its role in the central nervous system (CNS). It has been shown to exert neuroprotective effects in different models of brain injury. We studied whether neuroprotective effects assessed from the reduction of neuronal loss after transient brain ischemia are associated to the preservation of learning ability. Recombinant human erythropoietin (0.5-25 U) was injected in the lateral cerebral ventricle of gerbils that are subjected to temporary (3 min) bilateral carotid occlusion. Post-ischemic histological evaluation of CA1 area neuronal loss and passive avoidance test were performed. Treatment with recombinant human erythropoietin significantly reduced delayed neuronal death in the CA1 area of the hippocampus and prevented cognition impairment in the passive avoidance test. These data indicate that recombinant human erythropoietin neuroprotective effects in brain ischemia are associated with the preservation of learning function.
最近，人们对促红细胞生成素在中枢神经系统（CNS）中的作用进行了研究。研究表明，它在不同的脑损伤模型中发挥神经保护作用。我们研究了短暂性脑缺血后通过减少神经元损失评估的神经保护作用是否与学习能力的保留有关。将重组人促红细胞生成素（0.5 - 25 U）注入经历了3分钟双侧颈动脉闭塞的沙鼠侧脑室。进行了缺血后CA1区神经元损失的组织学评估和被动回避试验。重组人促红细胞生成素治疗显著减少了海马CA1区的迟发性神经元死亡，并在被动回避试验中预防了认知障碍。这些数据表明，重组人促红细胞生成素在脑缺血中的神经保护作用与学习功能的保留有关。
