X连锁无丙种球蛋白血症中的非进行性病毒性脊髓炎。

Non-progressive viral myelitis in X-linked agammaglobulinemia.

作者信息

Katamura Kenji, Hattori Haruo, Kunishima Tomoko, Kanegane Hirokazu, Miyawaki Toshio, Nakahata Tatsutoshi

机构信息

Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho Shogoin, Sakyo-ku 606-8507, Japan.

出版信息

Brain Dev. 2002 Mar;24(2):109-11. doi: 10.1016/s0387-7604(02)00002-5.

DOI:10.1016/s0387-7604(02)00002-5

PMID:11891104

Abstract

We report a 14-year-old boy with X-linked agammaglobulinemia (XLA) complicated by isolated non-progressive myelitis caused by Coxsackie virus B1. Despite the absence of immunoglobulin supplement and persistence of the virus for the initial 2 years, motor impairment did not show any progression for 3 years. This report shows that the prognosis of central nervous system infection in XLA is not determined by immunoglobulin levels alone, and that it is not always progressive or fatal. The balance between host immunity and the virulence of the causative virus may be involved in the prognosis of meningoencephalitis in XLA.

摘要

我们报告了一名14岁患有X连锁无丙种球蛋白血症（XLA）的男孩，其并发由B1型柯萨奇病毒引起的孤立性非进行性脊髓炎。尽管在最初2年未补充免疫球蛋白且病毒持续存在，但运动障碍在3年内未出现任何进展。本报告表明，XLA中枢神经系统感染的预后并非仅由免疫球蛋白水平决定，且并不总是进行性或致命的。宿主免疫力与致病病毒毒力之间的平衡可能与XLA脑膜脑炎的预后有关。