Yoder James A, Lloyd Michael, Zabrocki Luke, Auten Jonathan
Department of Emergency Medicine, Naval Medical Center, Portsmouth, Virginia.
School of Medicine, Eastern Virginia Medical School, Norfolk, Virginia.
J Emerg Med. 2017 Jul;53(1):e19-e23. doi: 10.1016/j.jemermed.2017.03.020. Epub 2017 Apr 12.
Enteroviral infections can cause acute flaccid paralysis secondary to anterior myelitis. Magnetic resonance imaging (MRI) is important in the diagnosis of this potentially devastating pediatric disease. Before the 2014 outbreak of Enterovirus D68 (EV-D68), the virus was considered a relatively benign disease.
A fully immunized 8-year-old boy was brought to the emergency department complaining of a cough, headache, neck pain, and right arm pain and weakness. Deep tendon reflexes in the weak arm could not be elicited. MRI of the brain and cervical spine revealed anterior myelitis of the cervical spine. The patient was given intravenous antibiotics, acyclovir, and methylprednisolone with no initial improvement. He was then given intravenous immunoglobulin over 3 days with improvement in symptoms. Nasal swab polymerase chain reaction revealed EV-D68. Despite medical management, the child was left with long-term motor disability in the effected extremity. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Acute flaccid paralysis is a potential devastating complication of enteroviral infections. Extremity complaints in the clinical setting of central nervous system infection should raise concern for encephalomyelitis. MRI is extremely helpful in establishing this diagnosis. Prevalence of non-polio enteroviral paralytic events is increasing in the United States. Potential EV-D68 cases should be reported to local health departments. Emergency medicine providers should consider this complication in the child with acute, unexplained significant respiratory illness with new neurologic complaints.
肠道病毒感染可导致继发于脊髓前角炎的急性弛缓性麻痹。磁共振成像(MRI)对于诊断这种可能具有毁灭性的儿科疾病很重要。在2014年肠道病毒D68(EV-D68)爆发之前,该病毒被认为是一种相对良性的疾病。
一名8岁已完全接种疫苗的男孩被带到急诊科,主诉咳嗽、头痛、颈部疼痛以及右臂疼痛和无力。患侧手臂无法引出深腱反射。脑部和颈椎的MRI显示颈椎脊髓前角炎。患者接受了静脉注射抗生素、阿昔洛韦和甲基泼尼松龙治疗,但最初并无改善。随后在3天内给予静脉注射免疫球蛋白,症状有所改善。鼻拭子聚合酶链反应检测显示为EV-D68。尽管进行了药物治疗,该患儿患侧肢体仍遗留长期运动功能障碍。急诊医生为何应了解此情况?:急性弛缓性麻痹是肠道病毒感染的一种潜在毁灭性并发症。在中枢神经系统感染的临床背景下出现肢体症状应引起对脑脊髓炎的关注。MRI对确诊非常有帮助。在美国,非脊髓灰质炎肠道病毒麻痹事件的发生率正在上升。潜在的EV-D68病例应报告给当地卫生部门。对于患有急性、不明原因的严重呼吸道疾病并伴有新的神经系统症状的儿童,急诊医学从业者应考虑到这种并发症。