Melo Justine, Toczyski David
Department of Biochemistry and Biophysics, Mount Zion Cancer Research Center, University of California, San Francisco, CA 94115, USA.
Curr Opin Cell Biol. 2002 Apr;14(2):237-45. doi: 10.1016/s0955-0674(02)00312-5.
Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.
近期对几种生物体内DNA损伤检查点的研究突出了该信号通路的保守性。检查点的信号转导通路由四类保守的分子组成：两类与磷脂酰肌醇3激酶具有同源性的大型蛋白激酶、三类与增殖细胞核抗原具有同源性的“传感器”蛋白、两类丝氨酸/苏氨酸（S/T）激酶以及两类S/T激酶的衔接蛋白。本综述比较了这四类检查点蛋白在人类和模式生物中的作用。
