DNA损伤检查点的统一观点。

A unified view of the DNA-damage checkpoint.

作者信息

Melo Justine, Toczyski David

机构信息

Department of Biochemistry and Biophysics, Mount Zion Cancer Research Center, University of California, San Francisco, CA 94115, USA.

出版信息

Curr Opin Cell Biol. 2002 Apr;14(2):237-45. doi: 10.1016/s0955-0674(02)00312-5.

DOI:10.1016/s0955-0674(02)00312-5

PMID:11891124

Abstract

Recent investigation of the DNA-damage checkpoint in several organisms has highlighted the conservation of this pathway. The checkpoint's signal transduction pathway consists of four conserved classes of molecules: two large protein kinases having homology to phosphatidylinositol 3-kinases, three "sensor" proteins with homology to proliferating cell nuclear antigen, two serine/threonine (S/T) kinases, and two adaptors for the S/T kinases. This review compares the role of these four classes of checkpoint proteins in humans and model organisms.

摘要

近期对几种生物体内DNA损伤检查点的研究突出了该信号通路的保守性。检查点的信号转导通路由四类保守的分子组成：两类与磷脂酰肌醇3激酶具有同源性的大型蛋白激酶、三类与增殖细胞核抗原具有同源性的“传感器”蛋白、两类丝氨酸/苏氨酸（S/T）激酶以及两类S/T激酶的衔接蛋白。本综述比较了这四类检查点蛋白在人类和模式生物中的作用。