Filho Jorge Sergio Reis, Soares Maria Fernanda, Wal Raquel, Christmann Romy Beatriz, Liu Christian Bark, Schmitt Fernando C
Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Rua Roberto Frias, S/N 4200 Porto, Portugal.
Diagn Cytopathol. 2002 Mar;26(3):150-3. doi: 10.1002/dc.10007.
Patients with rheumatoid disease may develop extra-articular lesions, affecting viscera and soft tissues. Pulmonary rheumatoid nodules show morphologic features reminiscent of a necrotizing inflammation of rheumatoid synovitis and differ from subcutaneous rheumatoid nodules only by their location, extension, and size. Although cytologic studies on pleural effusions in rheumatoid disease have long been performed, there are no more than three reports concerning the fine-needle aspiration (FNA) diagnosis of pulmonary rheumatoid nodules. The authors report on a case of a 62-yr-old woman with rheumatoid disease in whom a FNA diagnosis of pulmonary rheumatoid nodule was successfully performed. The authors highlight the main cytologic features of the entity and emphasise the high index of clinical and pathologic suspicions needed to be able to diagnose this lesion.
类风湿病患者可能会出现关节外病变，影响内脏和软组织。肺部类风湿结节的形态学特征让人联想到类风湿滑膜炎的坏死性炎症，仅在位置、范围和大小上与皮下类风湿结节有所不同。尽管长期以来一直在对类风湿病患者的胸腔积液进行细胞学研究，但关于肺类风湿结节细针穿刺抽吸（FNA）诊断的报告不超过三篇。作者报告了一例62岁患有类风湿病的女性病例，该病例通过FNA成功诊断为肺类风湿结节。作者强调了该病变的主要细胞学特征，并强调了诊断此病变所需的高度临床和病理怀疑指数。
