Undem Bradley J, Carr Michael J
Johns Hopkins Asthma and Allergy Center, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
Curr Allergy Asthma Rep. 2002 Mar;2(2):159-65. doi: 10.1007/s11882-002-0011-4.
Asthma is a syndrome characterized by reversible episodes of wheezing, cough, and sensations of chest tightness and breathlessness. These symptoms are secondary to changes in the activity of the nervous system. The mechanisms by which the nervous system is altered such that the symptoms of asthma occur have not yet been elucidated. Airway inflammation associated with asthma may affect neuronal activity at several points along the neural reflex pathway, including the function of the primary afferent (sensory) nerves, integration within the central nervous system, synaptic transmission within autonomic ganglia, and transmission at the level of the postganglionic neuroeffector junction. We provide a brief overview of these interactions and the relevance they may have to asthma.
哮喘是一种以喘息、咳嗽、胸闷和呼吸急促的可逆性发作为特征的综合征。这些症状是神经系统活动变化的继发表现。神经系统发生改变从而引发哮喘症状的机制尚未阐明。与哮喘相关的气道炎症可能在神经反射通路的多个环节影响神经元活动，包括初级传入（感觉）神经的功能、中枢神经系统内的整合、自主神经节内的突触传递以及节后神经效应器连接处的传递。我们简要概述这些相互作用及其与哮喘可能的相关性。
