Lutsep H, Clark W
Oregon Stroke Center, OHSU, Portland 97201, USA.
Curr Opin Investig Drugs. 2001 Dec;2(12):1732-6.
Neuroprotectants are drugs designed to treat stroke by preserving ischemic neurons in the penumbra. Despite numerous studies over the past ten years, no such drug has yet shown clinical efficacy. This article reviews those trials completed since 1999, including assessments of drugs that modify receptors or ion flow, block leukocyte adhesion receptors or stabilize membranes. In addition, ongoing trials and early trials using novel mechanisms of action, such as hypothermia and antioxidants, are discussed.
神经保护剂是一类旨在通过保护半暗带中的缺血神经元来治疗中风的药物。尽管在过去十年中进行了大量研究，但尚无此类药物显示出临床疗效。本文回顾了自1999年以来完成的那些试验，包括对改变受体或离子流、阻断白细胞粘附受体或稳定细胞膜的药物的评估。此外，还讨论了正在进行的试验以及采用诸如低温和抗氧化剂等新作用机制的早期试验。
