Oh Young Lyun, Song Sang-Yong, Ahn Geunghwan
Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Appl Immunohistochem Mol Morphol. 2002 Mar;10(1):62-6. doi: 10.1097/00129039-200203000-00011.
Maspin is a unique member of the serpin family, which inhibits tumor invasion and metastasis of the human breast and prostate cancers. Immunohistochemical evaluation of the maspin expression in pancreatic neoplasms has never been performed. The authors examined the expression of maspin in various pancreatic neoplasms to investigate its usefulness as an adjunct diagnostic marker. Formalin-fixed, paraffin-embedded tissue sections from 107 pancreatic neoplasms were immunostained with anti-maspin antibody using an EnVision+ System. Maspin was expressed in all ductal adenocarcinomas, of which 78.9% (30/38) were high expressors and 21.1% (8/38) were low expressors. All 13 intraductal papillary mucinous tumors and 11 of the 13 mucinous cystic tumors reacted to maspin with stronger expressions in carcinomatous lesions. In contrast, acinar cell carcinoma, pancreatic endocrine tumors, solid-pseudopapillary tumors, and serous cystadenomas demonstrated no maspin expression. In addition, nonneoplastic pancreatic parenchyma and chronic pancreatitis lacked expression. The current study suggests that maspin may be of importance in the pathobiology of pancreatic neoplasms with epithelial origin, especially pancreatic tumors that are composed of mucin-producing cells. It may be useful in separating ductal adenocarcinoma from acinar cell carcinoma, pancreatic endocrine tumor, solid-pseudopapillary tumor, and chronic pancreatitis, especially in needle biopsy specimens.
Maspin是丝氨酸蛋白酶抑制剂（serpin）家族的一个独特成员，它可抑制人类乳腺癌和前列腺癌的肿瘤侵袭和转移。从未有人对胰腺肿瘤中maspin表达进行过免疫组织化学评估。作者检测了maspin在各种胰腺肿瘤中的表达，以研究其作为辅助诊断标志物的效用。使用EnVision+系统，用抗maspin抗体对107例胰腺肿瘤的福尔马林固定、石蜡包埋组织切片进行免疫染色。Maspin在所有导管腺癌中均有表达，其中78.9%（30/38）为高表达，21.1%（8/38）为低表达。所有13例导管内乳头状黏液性肿瘤和13例黏液性囊性肿瘤中的11例对maspin有反应，癌性病变中表达更强。相比之下，腺泡细胞癌、胰腺内分泌肿瘤、实性假乳头状肿瘤和浆液性囊腺瘤未显示maspin表达。此外，非肿瘤性胰腺实质和慢性胰腺炎也无表达。当前研究表明，maspin可能在上皮起源的胰腺肿瘤的病理生物学中具有重要意义，尤其是由产生黏液的细胞组成的胰腺肿瘤。它可能有助于将导管腺癌与腺泡细胞癌、胰腺内分泌肿瘤、实性假乳头状肿瘤和慢性胰腺炎区分开来，尤其是在针吸活检标本中。
