微生物极简主义：病原菌中的基因组缩减

Microbial minimalism: genome reduction in bacterial pathogens.

作者信息

Moran Nancy A

机构信息

Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA.

出版信息

Cell. 2002 Mar 8;108(5):583-6. doi: 10.1016/s0092-8674(02)00665-7.

DOI:10.1016/s0092-8674(02)00665-7

PMID:11893328

Abstract

When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts.

摘要

当细菌谱系从自由生活或兼性寄生生命周期转变为与宿主的永久关联时，它们会经历基因和DNA的大量丢失。完整的基因组序列有助于我们理解极端的基因组缩减如何影响专性病原体和共生体的进化方向及代谢能力。