Kuropkat Christiane, Venkatesan T K, Caldarelli D D, Panje W R, Hutchinson J, Preisler H D, Coon J S, Werner J A
Department of Otolaryngology, Head and Neck Surgery, Philipps University, Deutschhausstr. 3, 35037, Marburg, Germany.
Auris Nasus Larynx. 2002 Apr;29(2):165-74. doi: 10.1016/s0385-8146(01)00129-8.
Abnormalities in genes regulating cell proliferation and death may affect disease outcome in squamous cell carcinoma (SCC) of the head and neck.
Proliferative activity (Histone H3 in-situ-hybridization (HISH) labeling index (LI)) and the genes and/or gene products of Cyclin D-1, c-erbB-2, Bcl-2, p21, and p53, were investigated in 35 patients with SCC of the oral cavity and oropharynx, previously studied for p27 expression.
Overexpression or very low expression of Cyclin D-1 was associated with unfavorable disease outcome and shorter time-to-recurrence. High c-erbB-2 expression was significantly associated with shorter overall survival and was synergistic with low p27 expression. Bcl-2, HISH LI, p21 expression, and p53 mutation and protein analysis were not significantly predictive, but there were trends suggesting shorter disease-free/overall survival for patients with undetectable Bcl-2, high HISH, and mutant p53.
Several cell proliferation and death regulators appeared to predict disease outcome. Limited evidence of cooperativeness among regulators was also seen.
调节细胞增殖和死亡的基因异常可能会影响头颈部鳞状细胞癌（SCC）的疾病预后。
对35例口腔和口咽鳞状细胞癌患者的增殖活性（组蛋白H3原位杂交（HISH）标记指数（LI））以及细胞周期蛋白D-1、c-erbB-2、Bcl-2、p21和p53的基因和/或基因产物进行了研究，这些患者之前已对p27表达进行过研究。
细胞周期蛋白D-1的过表达或极低表达与不良的疾病预后和较短的复发时间相关。高c-erbB-2表达与较短的总生存期显著相关，并且与低p27表达具有协同作用。Bcl-2、HISH LI、p21表达以及p53突变和蛋白分析没有显著的预测价值，但有趋势表明，Bcl-2检测不到、HISH高和p53突变的患者无病生存期/总生存期较短。
几种细胞增殖和死亡调节因子似乎可以预测疾病预后。同时也发现了调节因子之间有限的协同作用证据。
