Leonard R C, MacLennan I C, Smart Y, Vanhegan R I, Cuzick J
Int J Cancer. 1979 Oct 15;24(4):385-93. doi: 10.1002/ijc.2910240402.
The number of plasma cells in the lamina propria of the gut has been assessed in patients with multiple myeloma and other B-cell neoplasms. The total number of these plasma cells was reduced in most patients with myelomatosis and one-third of patients with lymphoplasmacytoid tumours. This reduction was not, however, seen in patients with other neoplasms of B-cell origin, although hypogammaglobulinaemia was common to all groups of patients. The depletion of gut plasma cell numbers was not uniform in myelomatosis patients. They showed selective loss of plasma cells with the same light chain isotype as that produced by the neoplastic clone.
已对多发性骨髓瘤和其他B细胞肿瘤患者肠道固有层中的浆细胞数量进行了评估。在大多数骨髓瘤患者和三分之一的淋巴浆细胞样肿瘤患者中，这些浆细胞的总数减少。然而，在其他B细胞起源的肿瘤患者中未观察到这种减少，尽管所有患者组均常见低丙种球蛋白血症。骨髓瘤患者肠道浆细胞数量的减少并不均匀。他们表现出与肿瘤克隆产生的轻链同种型相同的浆细胞选择性丢失。
