Wearne A, Joshua D E, Kronenberg H
Br J Haematol. 1984 Nov;58(3):483-9. doi: 10.1111/j.1365-2141.1984.tb03995.x.
Light chain isotype suppression in multiple myeloma has been reported in the plasma cells of the lamina propria of the gut (Leonard et al, 1979). In this paper we present further evidence of systemic suppression of the light chain isotype of the paraprotein expressed on normal peripheral blood lymphocytes in myeloma. Twenty patients with myeloma in plateau phase were monitored over 6 months for the expression of either kappa or lambda light chains on the surface of peripheral blood lymphocytes using monoclonal antibodies. The surface markers were analysed on an Ortho Spectrum III flow cytometer. Results of these studies indicate a selective suppression of the cells expressing the light chain isotype of the paraprotein in stable myeloma. Thus, in kappa myeloma there is a low kappa/lambda ratio and in lambda myeloma there is a high kappa/lambda ratio, and this suppression is lost with progressive disease.
肠道固有层浆细胞中存在多发性骨髓瘤轻链同种型抑制现象已有报道（伦纳德等人，1979年）。在本文中，我们提供了进一步的证据，证明骨髓瘤患者正常外周血淋巴细胞上表达的副蛋白轻链同种型存在全身抑制。使用单克隆抗体对20例处于平台期的骨髓瘤患者进行了6个月的监测，观察外周血淋巴细胞表面kappa或lambda轻链的表达情况。在Ortho Spectrum III流式细胞仪上分析表面标志物。这些研究结果表明，在稳定期骨髓瘤中，表达副蛋白轻链同种型的细胞受到选择性抑制。因此，在kappa骨髓瘤中kappa/lambda比值较低，而在lambda骨髓瘤中kappa/lambda比值较高，且随着疾病进展这种抑制作用消失。
