Tiemeier Henning, Pelzer Eva, Jönck Lothar, Möller Hans-Jürgen, Rao Marie Luise
Department of Psychiatry, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Neuropsychobiology. 2002;45(2):81-6. doi: 10.1159/000048681.
The present study evaluated the effect of slow wave sleep (SWS) deprivation on plasma levels of catecholamines in healthy male volunteers. Eleven volunteers spent 4 nights in the sleep laboratory (2 nights of habituation and 2 further nights); during the latter, 1 night served as control, and in the other, SWS deprivation was performed. Blood was drawn at 30-min intervals. SWS was reduced by 86%; no sleep stage 4 was observed during the SWS-deprived nights. SWS reduction was found not to correlate with catecholamine levels. However, epinephrine levels were found to be sensitive to sleep fragmentation. The time interval between arousals in the SWS-deprived night as well as the difference in sleep efficiency were related to increases in epinephrine levels (p < 0.01 and p < 0.025, respectively). These results support the view that continuity rather than the duration of SWS is important for the recuperative value of sleep.
本研究评估了慢波睡眠（SWS）剥夺对健康男性志愿者血浆儿茶酚胺水平的影响。11名志愿者在睡眠实验室度过了4个夜晚（2个适应夜晚和另外2个夜晚）；在后者中，1个夜晚作为对照，另一个夜晚进行SWS剥夺。每隔30分钟采集一次血液。SWS减少了86%；在SWS剥夺的夜晚未观察到睡眠4期。发现SWS减少与儿茶酚胺水平无关。然而，发现肾上腺素水平对睡眠片段化敏感。SWS剥夺夜晚的觉醒间隔时间以及睡眠效率的差异与肾上腺素水平的升高有关（分别为p < 0.01和p < 0.025）。这些结果支持了这样一种观点，即SWS的连续性而非持续时间对睡眠的恢复价值很重要。
