短暂性局灶性脑缺血后烟酰胺的治疗窗。

Therapeutic window for nicotinamide following transient focal cerebral ischemia.

作者信息

Ayoub Issam A, Maynard Kenneth I

机构信息

Neurophysiology Laboratory, Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

出版信息

Neuroreport. 2002 Feb 11;13(2):213-6. doi: 10.1097/00001756-200202110-00008.

DOI:10.1097/00001756-200202110-00008

PMID:11893912

Abstract

The therapeutic window with the neuroprotectant nicotinamide (NAm) was tested in a model of stroke. Either 2, 4 or 6 h after the onset of transient (2 h) focal cerebral ischemia, Wistar rats received either saline or NAm (500 mg/kg). Sensory and motor behavioral scores and weight of the animals were obtained before surgery, and 2 h, 3 and 7 days after stroke onset. Cerebral infarct volumes were measured on day 7 after sacrifice. NAm given 4 or 6 h after stroke onset significantly (p<0.05) reduced the cerebral infarction and improved the behavioral scores, respectively, compared to saline-injected animals. There was a non-significant improvement in weight gained by NAm-treated rats at 3 and 7 days following stroke compared to the saline-injected controls.

摘要

在中风模型中测试了神经保护剂烟酰胺（NAm）的治疗窗。在短暂性（2小时）局灶性脑缺血发作后2、4或6小时，Wistar大鼠接受生理盐水或NAm（500mg/kg）。在手术前以及中风发作后2小时、3天和7天获得动物的感觉和运动行为评分以及体重。在处死后第7天测量脑梗死体积。与注射生理盐水的动物相比，中风发作后4或6小时给予NAm分别显著（p<0.05）减少了脑梗死并改善了行为评分。与注射生理盐水的对照组相比，NAm治疗的大鼠在中风后3天和7天体重增加有不显著的改善。