用烟酰胺（维生素B3）进行治疗后，可减少雌性Sprague-Dawley大鼠和Wistar大鼠永久性局灶性脑缺血后的梗死体积。

Post-treatment with nicotinamide (vitamin B(3)) reduces the infarct volume following permanent focal cerebral ischemia in female Sprague-Dawley and Wistar rats.

作者信息

Sakakibara Y, Mitha A P, Ogilvy C S, Maynard K I

机构信息

Neurophysiology Laboratory, Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, EDR 414, Boston, MA 02114, USA.

出版信息

Neurosci Lett. 2000 Mar 10;281(2-3):111-4. doi: 10.1016/s0304-3940(00)00854-5.

DOI:10.1016/s0304-3940(00)00854-5

PMID:10704755

Abstract

Delayed treatment with nicotinamide (NAm) protects male rats against cerebral ischemia. Since the preponderant use of male animals in stroke research may produce results not applicable to female stroke patients due to gender-related differences, we examined whether delayed NAm treatment could protect female rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo). NAm (500 mg/kg) given intravenously, 2 h after MCAo, significantly reduced the infarct volume of female Sprague-Dawley (55%, P<0.05) and Wistar rats (60%, P<0.05) rats when compared with saline-injected controls. These studies confirm that NAm is neuroprotective specifically at the dose of 500 mg/kg in rats. The novel findings are that this neuroprotection occurs in female, as well as male rats, and that the neuroprotection observed is more robust when administered as an intravenous bolus compared with intraperitoneal administration.

摘要

烟酰胺（NAm）延迟治疗可保护雄性大鼠免受脑缺血损伤。由于在中风研究中主要使用雄性动物，可能会因性别差异而产生不适用于女性中风患者的结果，因此我们使用永久性大脑中动脉闭塞（MCAo）模型研究了延迟NAm治疗是否能保护雌性大鼠免受局灶性脑缺血损伤。MCAo后2小时静脉注射NAm（500mg/kg），与注射生理盐水的对照组相比，显著降低了雌性Sprague-Dawley大鼠（55%，P<0.05）和Wistar大鼠（60%，P<0.05）的梗死体积。这些研究证实，NAm在大鼠中剂量为500mg/kg时具有特异性神经保护作用。新的发现是，这种神经保护作用在雌性和雄性大鼠中均存在，并且与腹腔注射相比，静脉推注时观察到的神经保护作用更强。