Tashev T, Chernev K, Ivanov E, Zhoteva D
Vutr Boles. 1975;14(1):17-23.
Liver is the main organ associated with alcohol oxidation. The definite liver enzymes role is not elucidated as yet, that participates in alcohol metabolism. The nutrient factors are of a great importance for the development of the alcoholic liver lesions and for the induction of liver enzymes under alcohol effect. Alcohol effect was studied in 80 male albino rats, Wistar strain, as well as some nutritional diets upon microsomal enzymes--cytochrome P-450, aniline-hydroxilase aminopyrine-demetilase., ADH and DALA-C. The changes, developed in the body weight are discussed as well as the liver weight and the microsomal protein under alcohol effect and the respective nutritional regimens. Alcohol, given in a dose of 4g/kg body weight, in the course of 60 days, induces but slightly the microsomal enzymes cytochrome P-450 and aniline-hydroxilase and does not induce aminopyrine-demetilase. ADH activity decrease with the chronic alcohol loading. Mitochondrial enzyme DALA-C is moderately induced by alcohol. Lipid and protein role is decisive in the induction process while the carbohydrate role is less.
肝脏是与酒精氧化相关的主要器官。参与酒精代谢的肝脏酶的确切作用尚未阐明。营养因素对于酒精性肝损伤的发展以及酒精作用下肝脏酶的诱导具有重要意义。在80只雄性Wistar品系白化大鼠中研究了酒精作用以及一些营养饮食对微粒体酶——细胞色素P - 450、苯胺羟化酶、氨基比林脱甲基酶、乙醇脱氢酶（ADH）和DALA - C的影响。还讨论了在酒精作用以及相应营养方案下体重、肝脏重量和微粒体蛋白的变化。以4g/kg体重的剂量给予酒精，持续60天，对微粒体酶细胞色素P - 450和苯胺羟化酶的诱导作用轻微，对氨基比林脱甲基酶无诱导作用。慢性酒精负荷会使ADH活性降低。酒精对线粒体酶DALA - C有中度诱导作用。在诱导过程中，脂质和蛋白质起决定性作用，而碳水化合物的作用较小。
