Antal M, Nagy K, Bedö M B
Ann Nutr Metab. 1981;25(4):239-44. doi: 10.1159/000176501.
Effects of fructose, starch, lactose plus starch and ethanol on the drug-metabolizing enzyme system of the liver were analyzed in rats fed fructose, starch or lactose plus starch diets for 21 days. The activity of aminopyrine demethylase and aniline hydroxylase and the level of cytochrome P-450 increased significantly in rats fed lactose plus starch compared to the groups fed fructose or starch diets. The activity of aniline hydroxylase increased as a result of ethanol, independent of the nature of the carbohydrate but in this case the highest activity was also found in the livers of rats previously fed a lactose plus starch diet.
在喂食果糖、淀粉或乳糖加淀粉饮食21天的大鼠中，分析了果糖、淀粉、乳糖加淀粉和乙醇对肝脏药物代谢酶系统的影响。与喂食果糖或淀粉饮食的组相比，喂食乳糖加淀粉的大鼠中氨基比林脱甲基酶和苯胺羟化酶的活性以及细胞色素P - 450的水平显著增加。乙醇会使苯胺羟化酶的活性增加，这与碳水化合物的种类无关，但在这种情况下，活性最高的也是先前喂食乳糖加淀粉饮食的大鼠肝脏。
