Fusconi Massimo, Magliulo Giuseppe, Della Rocca Carlo, Marcotullio Dario, Suriano Maria, de Vincentiis Marco
ENT Department, "La Sapienza" University, Rome, Italy.
Am J Otolaryngol. 2002 Mar-Apr;23(2):108-11. doi: 10.1053/ajot.2002.30628.
Leiomyosarcoma of the paranasal sinuses is uncommon and has an aggressive clinical behavior. Only 28 cases have been described in the literature, and, of these, only 3 patients treated with surgery had a disease-free survival. In this report, we describe the clinical history of a 57-year-old woman with a leiomyosarcoma of the paranasal sinuses successfully treated with a combination of surgery, radiation therapy, and chemotherapy. We obtained a total response with ifosfamide, doxorubicin, dacarbazine, and epirubicin. This case report emphasizes the possibility of treating this aggressive tumor with chemotherapy in accordance with the same therapy used in the treatment of uterine leiomyosarcomas.
鼻窦平滑肌肉瘤并不常见，具有侵袭性的临床行为。文献中仅描述了28例，其中仅3例接受手术治疗的患者无病生存。在本报告中，我们描述了一名57岁女性鼻窦平滑肌肉瘤患者的临床病史，该患者通过手术、放疗和化疗联合治疗成功治愈。我们使用异环磷酰胺、阿霉素、达卡巴嗪和表柔比星获得了完全缓解。本病例报告强调了按照治疗子宫平滑肌肉瘤的相同疗法用化疗治疗这种侵袭性肿瘤的可能性。
