Rumen F, Souied E, Oubraham H, Coscas G, Soubrane G
Clinique ophtalmologique universitaire de Créteil, Centre Hospitalier Intercommunal, 40, avenue de Verdun, 94010 Créteil.
J Fr Ophtalmol. 2001 Oct;24(8):854-9.
Macular edema is frequently responsible for loss of central vision in patients affected with retinitis pigmentosa (RP). This macular edema can be treated with acetazolamide. Our purpose was to evaluate optical coherence tomography (OCT) examination in the follow-up of macular edema in RP. In addition, we tried to evaluate the minimal efficient dose of acetazolamide, using means other than fundus examination or fluorescein angiography. We report the cases of 5 patients affected with typical retinitis pigmentosa and fundus appearance of macular edema. These patients received oral acetazolamide treatment (500 mg/d). The OCT examinations were performed before and during treatment, which allowed us to demonstrate, quantify and monitor the progression of macular edema during treatment. OCT appears to be a useful tool in the follow-up of patients affected with macular edema and RP. This noninvasive examination contributes to improving our strategy in treating patients.
黄斑水肿常常导致色素性视网膜炎（RP）患者中心视力丧失。这种黄斑水肿可用乙酰唑胺治疗。我们的目的是评估光学相干断层扫描（OCT）检查在RP黄斑水肿随访中的作用。此外，我们试图用眼底检查或荧光素血管造影以外的方法评估乙酰唑胺的最小有效剂量。我们报告了5例典型色素性视网膜炎且有黄斑水肿眼底表现患者的病例。这些患者接受口服乙酰唑胺治疗（500毫克/天）。在治疗前和治疗期间进行了OCT检查，这使我们能够证明、量化并监测治疗期间黄斑水肿的进展。OCT似乎是随访RP黄斑水肿患者的有用工具。这种非侵入性检查有助于改进我们治疗患者的策略。
