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大鼠纹状体中吡贝地尔及其活性代谢物（S-584）的水平。

Levels of piribedil and its active metabolite (S-584) in the rat striatum.

作者信息

Fanelli R, Frigerio A, Garattini S

出版信息

Xenobiotica. 1975 Oct;5(10):595-600. doi: 10.3109/00498257509056129.

DOI:10.3109/00498257509056129
PMID:1189457
Abstract
  1. A gas chromatographic-mass fragmentographic method has been developed to determine piribedil and its metabolite S-584, using diazepam as internal standard. The metabolite was derivatized as a trimethylsilyl ether for gas chromatographic analysis. The minimum detectable amount of piribedil and the metabolite was 10 ng/g tissue. 2. Levels of piribedil and its metabolite in the striatum were determined by mass fragmentography.
摘要
  1. 已开发出一种气相色谱 - 质谱碎片分析法，以地西泮为内标物来测定吡贝地尔及其代谢物S - 584。该代谢物被衍生化为三甲基硅醚用于气相色谱分析。吡贝地尔及其代谢物的最低检测量为10 ng/g组织。2. 通过质谱碎片分析法测定纹状体中吡贝地尔及其代谢物的含量。

相似文献

1
Levels of piribedil and its active metabolite (S-584) in the rat striatum.大鼠纹状体中吡贝地尔及其活性代谢物（S-584）的水平。
Xenobiotica. 1975 Oct;5(10):595-600. doi: 10.3109/00498257509056129.
2
Differential labelling of dopamine receptors in rat brain in vivo: comparison of [3H]piribedil, [3H]S 3608 and [3H]N,n-propylnorapomorphine.大鼠脑内多巴胺受体的体内差异标记：[3H]哌立地尔、[3H]S 3608和[3H]N，N-丙基去甲阿扑吗啡的比较
Eur J Pharmacol. 1983 Jan 28;87(1):85-94. doi: 10.1016/0014-2999(83)90053-5.
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Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat.精神药物丁螺环酮、MJ - 13805和匹莫齐特及其共同活性代谢物1 - (2 - 嘧啶基) - 哌嗪在大鼠体内的处置情况。
Xenobiotica. 1985 Oct;15(10):835-44. doi: 10.3109/00498258509045035.
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Apomorphine and piribedil in rats: biochemical and pharmacologic studies.大鼠体内的阿扑吗啡与吡贝地尔：生化与药理学研究
Adv Neurol. 1975;9:307-26.
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Dopaminergic-cholinergic interaction in the striatum: studies with piribedil.纹状体中多巴胺能与胆碱能的相互作用：吡贝地尔的研究
Adv Neurol. 1975;9:257-72.
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Determination of piribedil in biological materials by gas-liquid chromatography-mass fragmentography.气液色谱-质谱碎片分析法测定生物材料中的匹立地尔
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Gas chromatographic-mass fragmentographic determination of trazodone in rat plasma.
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Yawning elicited by systemic and intrastriatal injection of piribedil and apomorphine in the rat.全身性及纹状体内注射匹立哌唑和阿扑吗啡诱发大鼠打哈欠。
Psychopharmacology (Berl). 1985;86(1-2):175-81. doi: 10.1007/BF00431705.
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[Pharmacology of piribedil].[吡贝地尔的药理学]
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Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application.开发并验证用于测定大鼠血浆和脑组织中吡贝地尔的具有二极管阵列检测器（PDA）和荧光检测功能的快速灵敏液相色谱方法及其药代动力学应用。
Biomed Chromatogr. 2018 Oct;32(10):e4303. doi: 10.1002/bmc.4303. Epub 2018 Jul 2.

引用本文的文献

1
Kinetics of piribedil and effects on dopamine metabolism: hepatic biotransformation is not a determinant of its dopaminergic action in rats.
Psychopharmacology (Berl). 1991;105(4):541-5. doi: 10.1007/BF02244377.
2
Solid-phase extraction of piribedil and its metabolites from plasma and urine without and after deconjugation, by high performance liquid chromatography.通过高效液相色谱法对血浆和尿液中未结合及结合后去结合的吡贝地尔及其代谢物进行固相萃取。
Eur J Drug Metab Pharmacokinet. 1992 Jul-Sep;17(3):205-11. doi: 10.1007/BF03190147.