Dahm Anders Erik Astrup, Brørs Odd
Medisinsk divisjon, Ullevål universitetssykehus 0407 Oslo.
Tidsskr Nor Laegeforen. 2002 Jan 30;122(3):278-80.
Drug interactions may cause diverse clinical symptoms.
A case history.
A 58-year-old man was admitted to hospital with suspected stroke. It turned out that his neurological symptoms were caused by phenytoin intoxication. The patient had previously taken phenytoin for epilepsy for nine years without being intoxicated. Hospital records revealed that he had received ticlopidine for two weeks in connection with a coronary stent procedure five to seven weeks earlier. The probable cause of the phenytoin intoxication was interaction between ticlopidine and phenytoin.
This case history demonstrates that apparently unrelated drugs may interact and result in serious toxicity.
药物相互作用可能导致多种临床症状。
病例报告。
一名58岁男性因疑似中风入院。结果发现他的神经症状是由苯妥英中毒引起的。该患者此前服用苯妥英治疗癫痫九年未发生中毒。医院记录显示，他在五至七周前因冠状动脉支架手术接受了两周的噻氯匹定治疗。苯妥英中毒的可能原因是噻氯匹定与苯妥英之间的相互作用。
该病例报告表明，看似无关的药物可能相互作用并导致严重毒性。
