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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Moore R G, Robertson A V, Smyth M P, Thomas J, Vine J

Xenobiotica. 1975 Nov;5(11):687-96. doi: 10.3109/00498257509056138.

Chlormethiazole and five of its metabolites excreted in urine in man have been investigated by g.l.c.-mass spectrometry. 2. Four metabolites have been identified by comparison with authentic compounds as 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyl)-4-methylthiazole, 5-(2-hydroxyethyl)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid; 4-methyl-5-thiazoleacetaldehyde is proposed for the other metabolite. 3. The amounts of chlormethiazole and its identified metabolites excreted in urine have been quantitatively determined after a single oral dose in three healthy adults. Approximately 16% of the dose was excreted as chlormethiazole, 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyx)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid.

已采用气相色谱-质谱联用技术对人尿中排泄的氯美噻唑及其五种代谢物进行了研究。2. 通过与标准化合物比较，已鉴定出四种代谢物分别为5-乙酰基-4-甲基噻唑、5-(1-羟乙基)-4-甲基噻唑、5-(2-羟乙基)-4-甲基噻唑和4-甲基-5-噻唑乙酸；另一种代谢物推测为4-甲基-5-噻唑乙醛。3. 对三名健康成年人单次口服给药后尿中排泄的氯美噻唑及其已鉴定代谢物的量进行了定量测定。约16%的剂量以氯美噻唑、5-乙酰基-4-甲基噻唑、5-(1-羟乙基)-4-甲基噻唑和4-甲基-5-噻唑乙酸的形式排泄。

Moore R G, Robertson A V, Smyth M P, Thomas J, Vine J

Xenobiotica. 1975 Nov;5(11):687-96. doi: 10.3109/00498257509056138.

Chlormethiazole and five of its metabolites excreted in urine in man have been investigated by g.l.c.-mass spectrometry. 2. Four metabolites have been identified by comparison with authentic compounds as 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyl)-4-methylthiazole, 5-(2-hydroxyethyl)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid; 4-methyl-5-thiazoleacetaldehyde is proposed for the other metabolite. 3. The amounts of chlormethiazole and its identified metabolites excreted in urine have been quantitatively determined after a single oral dose in three healthy adults. Approximately 16% of the dose was excreted as chlormethiazole, 5-acetyl-4-methylthiazole, 5-(1-hydroxyethyx)-4-methylthiazole and 4-methyl-5-thiazoleacetic acid.

已采用气相色谱-质谱联用技术对人尿中排泄的氯美噻唑及其五种代谢物进行了研究。2. 通过与标准化合物比较，已鉴定出四种代谢物分别为5-乙酰基-4-甲基噻唑、5-(1-羟乙基)-4-甲基噻唑、5-(2-羟乙基)-4-甲基噻唑和4-甲基-5-噻唑乙酸；另一种代谢物推测为4-甲基-5-噻唑乙醛。3. 对三名健康成年人单次口服给药后尿中排泄的氯美噻唑及其已鉴定代谢物的量进行了定量测定。约16%的剂量以氯美噻唑、5-乙酰基-4-甲基噻唑、5-(1-羟乙基)-4-甲基噻唑和4-甲基-5-噻唑乙酸的形式排泄。