Mercer J G
Molecular Neuroendocrinology Group, Aberdeen Centre for Energy Regulation and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, UK.
Nutr Metab Cardiovasc Dis. 2001 Aug;11(4 Suppl):114-7.
This paper outlines the concepts and objectives behind the Fifth Framework Programme 'Diet and Obesity', scheduled to run from February 2001 to January 2004 with financial support from the European Commission. The objective is to identify the causes of weight gain on an energy-dense, high fat diet, and apply findings in the diagnosis, prevention and management of obesity. Molecular, physiological, behavioural and clinical approaches will be applied to the study of the mechanisms underlying diet preferences and susceptibility to weight gain, in both humans and laboratory rodents. This strategy is based on the observation that not all individuals habitually eating a high fat diet are obese; some have a similar body mass index (BMI) to low fat consumers despite the consumption of substantially more fat (and energy). The project will investigate why some individuals preferentially select a high fat diet, and how genetic background interacts with diet to confer susceptibility or resistance to obesity. Improved diagnosis of individuals at risk may allow treatment and preventive measures, including advice during pregnancy, to be more targeted. The effect of early life nutrition on dietary preferences, susceptibility to obesity, and the programming of brain signalling systems will be investigated in parallel clinical and rodent studies.
本文概述了第五框架计划“饮食与肥胖”背后的概念和目标，该计划定于2001年2月至2004年1月实施，由欧盟委员会提供资金支持。其目标是确定在高能量、高脂肪饮食下体重增加的原因，并将研究结果应用于肥胖症的诊断、预防和管理。分子、生理、行为和临床方法将应用于研究人类和实验啮齿动物饮食偏好及体重增加易感性的潜在机制。该策略基于这样的观察结果：并非所有习惯性食用高脂肪饮食的个体都会肥胖；尽管某些人摄入的脂肪（和能量）明显更多，但他们的体重指数（BMI）与低脂饮食者相似。该项目将研究为何有些人优先选择高脂肪饮食，以及基因背景如何与饮食相互作用，从而导致肥胖易感性或抗性。对有风险个体的诊断改善可能会使治疗和预防措施（包括孕期建议）更具针对性。将通过平行的临床和啮齿动物研究，调查早期营养对饮食偏好、肥胖易感性以及大脑信号系统编程的影响。
