Wang C L
Muscle and Motility Group, Boston Biomedical Research Institute, Watertown, MA 02472, USA.
Cell Biochem Biophys. 2001;35(3):275-88. doi: 10.1385/cbb:35:3:275.
Smooth muscles exist in the wall of hollow organs in our body and are responsible for controlling the flow of vital fluids that are essential for the normal function of the cardiovascular, respiratory, digestive, and reproductive systems. Many diseases, such as hypertension, asthma, indigestion, and premature birth, may attribute to malfunction of smooth-muscle contraction. It is therefore important to decipher how smooth-muscle contraction is regulated. This review attempts to give a brief overview of current understanding about the molecular mechanisms of smooth-muscle regulation and, in particular, to discuss possible roles of caldesmon in this regulatory process.
平滑肌存在于我们身体中空器官的壁中，负责控制重要液体的流动，这些液体对于心血管、呼吸、消化和生殖系统的正常功能至关重要。许多疾病，如高血压、哮喘、消化不良和早产，可能归因于平滑肌收缩功能异常。因此，弄清楚平滑肌收缩是如何调节的很重要。这篇综述试图简要概述目前对平滑肌调节分子机制的理解，特别是讨论钙调蛋白在这一调节过程中的可能作用。
